In‐depth molecular profiling of the biphasic components of uterine carcinosarcomas
نویسندگان
چکیده
منابع مشابه
In‐depth molecular profiling of the biphasic components of uterine carcinosarcomas
Uterine carcinosarcoma is a clinically aggressive malignancy composed of a mix of carcinomatous and sarcomatous elements. We performed targeted next-generation sequencing of 27 uterine cancer and sarcoma genes together with immunohistochemical analyses of selected proteins in 30 uterine carcinosarcomas. This included 13 cases in which the distinct carcinoma and sarcoma components were sequenced...
متن کاملMalignant biphasic uterine tumours: carcinosarcomas or metaplastic carcinomas?
Uterine carcinosarcomas (malignant mixed Mullerian tumours) are highly aggressive and have traditionally been regarded as a subtype of uterine sarcoma. However, in recent years convincing evidence has suggested that most, but not all, are monoclonal in origin rather than true collision tumours. Data confirm that the carcinomatous element is the "driving force" and that the sarcomatous component...
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Uterine carcinosarcoma, also known as Malignant Mixed Müllerian Tumour, is a high-grade biphasic neoplasm composed of sarcomatous elements thought to originate via transdifferentiation from high-grade endometrial carcinoma. To identify molecular factors contributing to the histogenesis of this tumour, we analyzed DNA extracted from matched carcinoma and sarcoma components from 12 cases of carci...
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چکیده ندارد.
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ژورنال
عنوان ژورنال: The Journal of Pathology: Clinical Research
سال: 2015
ISSN: 2056-4538,2056-4538
DOI: 10.1002/cjp2.18